complicado mecanismo de acción antitumoral como con sus efectos .. inhibidores de la topoisomerasa II (doxorrubicina, etopósido. mecanismo de acción de antineoplasicos. AV Doxorrubicina (antraciclina). – Lesión del ADN. –Inhibición topoisomerasa II. –Vía intravenosa. Abraxane (nombre genérico: paclitaxel unido a albúmina (nab-paclitaxel)) · Adriamicina (nombre genérico: doxorrubicina) · Carboplatino.
|Published (Last):||6 July 2018|
|PDF File Size:||19.35 Mb|
|ePub File Size:||2.97 Mb|
|Price:||Free* [*Free Regsitration Required]|
This simple act of changing the conformation of DNA can interfere with strand elongation by inhibiting DNA polymerase and can inhibit protein synthesis due to effects on RNA polymerase. Conjunctivitis and keratitis have been reported with epirubicin chemotherapy.
This may compromise the efficacy of the uricosuric agents probenecid and sulfinpyrazone. The overall survival following both regimens was not superior to other treatments. The resulting hyperuricemia could aggravate foxorrubicina or urate nephrolithiasis. The red urine should not be confused with hematuria. Most patients recover by the third week of therapy. Topical cooling does not reduce anthracycline skin concentrations but decreases cellular uptake of anthracyclines thereby decreasing the cytotoxic effect.
Men may experience spermatogenesis inhibition. Prospective and randomized trial of lipiodol-transcatheter arterial chemoembolization treatment of hepatocellular carcinoma: Serum bilirubin and AST levels should be evaluated before and during treatment with epirubicin.
This doxorrubbicina protein functions as an energy-dependant drug doxorruvicina pump in resistant cells. The addition of cyclosporine or valspodar to epirubicin therapy may result in increases in AUC for both epirubicin and epirubicinol possibly due to a decrease in clearance of parent drug, a decrease in metabolism of epirubicinol, or an increase in intracellular epirubicin concentrations. The French Epirubicin Study Group. The ECF regimen resulted in an increased d and survival benefit for patients with previously untreated gastric cancer or head and neck cancer.
Serum creatinine levels should be assessed before dee during epirubicin treatment. The epirubicin combination was significantly more myelosuppressive.
Weekly paclitaxel and epirubicin as second-line therapy of metastatic breast cancer: It is thought that myocardial damage and ventricular dysfunction progress and lead to late-onset cardiac dysfunction following treatment with anthracyclines. All surviving patients improved or maintained their prior responses following high-dose therapy.
Women may experience irreversible amenorrhea, premature menopause, and decreased fertility. Hyperpigmentation of the oral mucosa may also occur. Bolus vincristine and epirubicin with cyclophosphamide and dexamethasone VECD meccanismo induction and salvage treatment in multiple myeloma.
Dosage adjustments of antigout agents may be necessary to control hyperuricemia.
Doxorrubicina – Viquipèdia, l’enciclopèdia lliure
Epirubicin and other anthracyclines induce cytotoxicity through several different mechanisms. Epirubicin should not be administered during pregnancy because of the possibility of teratogenic effects. The dose of epirubicin should be adjusted for elevations in the total bilirubin or AST because these patients will have a decreased clearance of epirubicin with an increase in overall toxicity see Dosage.
Epirubicin-induced cardiomyopathy and congestive heart failure CHF is associated with the cumulative dose of epirubicin. Two cases of acute lymphoid leukemia ALL have been reported in patients receiving epirubicin.
Previous irradiation to the left chest is associated with an increased risk of developing CHF and an accelerated mortality. Stomatitis and esophagitis can occur in 2 to 3 days following initiation of chemotherapy and is characterized by oral bleeding, burning, erythema, infections, and oral ulceration. She received the last dose at 34 weeks of the pregnancy and delivered a healthy baby at 35 weeks. Symptoms may last up to an hour and may be treated with qccion, antihistamines and ice mecanizmo.
Epirubicin is considered cell cycle non-specific.
Dosage For the adjuvant treatment of breast cancer: However, later events several months to years after ending treatment have been reported. Cimetidine therapy should be stopped during epirubicin therapy. Surgical follow-up is indicated if pain and swelling at the site mscanismo 2 weeks after the extravasation. Patients with a history of varicella zoster, other herpes infections e.
Other mechanisms of resistance include changes in topoisomerase II and glutathione activity. A review of its use as a cardioprotective agent in patients receiving anthracycline-based chemotherapy.
It does not appear dexrazoxane affects the clinical efficacy or non-cardiac toxicity of epirubicin. Breast-feeding is contraindicated during epirubicin therapy.
It is not known if epirubicin is excreted in human breast milk but has been detected in breast milk of animals.